Proof of concept.

Why does BRAF inhibition mono therapy not work in BRAF mutant Colon Cancer

BRAF inhibition has proven to be a very effective strategy in BRAF mutant melanoma. Response rates in BRAF colon cancer show limited, if any benefit of BRAF inhibition. The question is what pathway gets activated after blockage of BRAF, that makes colon cancer resistant.

BRAF inhibition has proven to be a very effective strategy in BRAF mutant melanoma. Response rates in BRAF colon cancer show limited, if any benefit of BRAF inhibition. The question is what pathway gets activated after blockage of BRAF, that makes colon cancer resistant.

What pathway is the feedback loop of BRAF inhibition, synthetic lethal screen

The image describes a synthetic lethal screen. 

The image describes a synthetic lethal screen. 

confirmation of cell line data in mous xenograft models

Mouse models confirm the initial cell line findings

Mouse models confirm the initial cell line findings